写的:
Executive Director, Computational Pathology, 肿瘤学 R&D
Vice President, Image Data Sciences, Computational Pathology, 肿瘤学 R&D
在澳门葡京网赌游戏, we’re pioneering new computational pathology approaches, 将数字病理学和大数据与尖端人工智能相结合,增强患者选择,实现更个性化的治疗, with the ultimate goal of improving patient outcomes.
Beyond the microscope: computational pathology
In 1838, 德国病理学家Johannes m
Over the past two decades we have seen the advent of technologies, such as high-resolution slide scanning, 创建免疫组织化学染色玻片的数字图像,可以很容易地查看和共享.2
数据科学和计算的进步使澳门葡京赌博游戏能够将数字病理图像与基因组相结合, 放射学, clinical and other data, applying deep learning algorithms to gain novel insights.
通过从这些复杂的数据集中提取和分析客观和临床相关的信息, we can ‘see’ more than the human eye ever could to understand disease and guide treatment.
Known as computational pathology, 这种方法利用人工智能的力量来增强肿瘤患者的选择3 – a key part of our precision medicine strategy.
观看下面的视频,了解更多关于澳门葡京赌博游戏如何利用计算病理学来彻底改变癌症治疗和诊断的发展:
Transformational medicines need transformational diagnostics
As our understanding of disease and the options to treat it increases, 因此,澳门葡京赌博游戏需要一种精确的医疗方法,以确保澳门葡京赌博游戏用正确的药物治疗正确的病人, earlier in their disease.
例如, 抗体-药物偶联物(adc)依靠单克隆抗体独特的靶向能力来杀死癌细胞并减少对正常细胞的损伤.4 类似的, 免疫疗法是基于对肿瘤微环境和癌细胞用来逃避免疫系统的防御机制的了解.5
Conventional pathology depends on manual, 对组织生物标志物进行主观评分,以帮助澳门葡京赌博游戏了解疾病进展并为患者选择最佳治疗方法. In addition, it is usually based on a limited subset of cells within a sample.
当涉及到这些新疗法时,获取更多关于潜在肿瘤生物学的定量信息的计算方法对于支持临床决策的不断发展的需求至关重要.6
澳门葡京赌博游戏在澳门葡京网赌游戏正在开发的计算病理学工具使澳门葡京赌博游戏能够以前所未有的细节分析每张幻灯片上数十万个细胞, much faster than previously possible.
这一代丰富的数据集让澳门葡京赌博游戏对肿瘤内部发生的情况有了更好的了解, 量化基于组织的生物标志物,帮助澳门葡京赌博游戏选择最有可能对治疗有反应的患者.
Quantitative Continuous Scoring: a new frontier in diagnostics
Quantitative Continuous Scoring, 或质量控制, 是澳门葡京赌博游戏的小说吗, fully automated computational pathology solution.7 它利用人工智能在免疫组织化学染色的癌症组织中获得的数字整张幻灯片图像中提供有关生物标志物的详细数据.7
Not only does QCS look for the presence or absence of a biomarker, 但它也量化了染色的强度及其在亚细胞区室中的位置, 比如膜, 细胞质和细胞核, and analyses the broader spatial organisation of the tissue.8 这一信息与细胞内吸收的adc等药物特别相关, 帮助澳门葡京赌博游戏预测它们对旁观者细胞的影响,并进一步了解它们的作用机制.
现在, we’re pioneering the use of QCS within our clinical trial portfolio, with regulatory approval as a first-in-class AI-driven diagnostic as a future goal. We are also exploring its use in multiple indications, such as non-small cell lung cancer and hepatocellular carcinoma, 并将其设想为临床试验和癌症治疗中患者选择的宝贵工具.
Seeing more from every slide
Computational pathology enables us to go much further than a single snapshot of a slide, moving towards a multi-layered, fully integrated ‘geographical map’ of the tumour and its microenvironment. Our ambition is to apply these tools across our portfolio, supporting drug development and enhancing patient selection for clinical trials in oncology.
It’s an incredibly exciting time for the field. 澳门葡京赌博游戏有新的工具,新的药物和数字方法,这些都为这项技术打开了大门. 澳门葡京赌博游戏也看到监管环境对这些新型诊断方法的热情和积极举措不断增长, suggesting the time is right for a step change.
Collaboration with pathologists, 仪器制造商和更广泛的病理界对建立常规至关重要, 人工智能驱动的诊断,并使这项强大的技术更广泛地用于临床试验中的患者. 澳门葡京赌博游戏正在与全球伙伴合作,帮助建立实现这一目标所需的诊断实验室基础设施.
除了通过提供更深入和准确的诊断为患者带来好处之外, 这项技术还将解放病理学家的时间,使他们能够专注于更复杂的病例,从而增加有影响力的分析和价值.
在澳门葡京网赌游戏, 澳门葡京赌博游戏相信,计算病理学将为下一代癌症治疗和诊断的发展奠定基础, 改变澳门葡京赌博游戏进行临床研究的方式,最终导致新的治疗方法或改善患者的治疗效果.